Experiencing multiple miscarriages can be emotionally difficult, and it may lead you to consider IVF or further fertility investigation. Team Miracle Cyprus IVF Centre identifies recurrent miscarriage as one of the reasons patients may seek specialist fertility support.
The appropriate tests depend on your medical history and previous fertility treatment. Your fertility specialist can review your history and recommend investigations that may help identify factors affecting embryo development, implantation or pregnancy.
What Tests May Be Recommended After Multiple Miscarriages?
Depending on your individual circumstances, your fertility specialist may consider:
- Hormone blood tests
- Ultrasound scans
- Genetic or chromosomal testing
- Preimplantation Genetic Testing (PGT)
- Endometrial or uterine investigations
- Sperm analysis or additional sperm testing
- Immune-related assessments in selected cases
Not every patient requires all of these tests. The purpose of further investigation is to understand your individual circumstances and determine the most appropriate treatment approach.
1. Hormone Blood Tests
Hormonal factors may be reviewed as part of a fertility assessment.
For patients using their own eggs, Team Miracle Cyprus IVF Centre’s standard pre-treatment fertility assessment includes blood tests for:
- FSH
- LH
- AMH
- TSH
- E2 (oestradiol)
- Prolactin
These tests are carried out between days 2 and 4 of the menstrual cycle.
Additional hormonal evaluation may be considered depending on your medical history and previous treatment.
2. Ultrasound Assessment
An ultrasound scan can form part of the fertility assessment before IVF.
Team Miracle Cyprus IVF Centre requires a trans-vaginal antral follicle count (AFC) for patients using their own eggs. The scan provides information about the ovaries before treatment begins.
Further assessment of the uterus may also be considered where there are concerns about implantation or previous pregnancy loss.
3. Genetic Testing of Embryos
Genetic factors can be relevant when investigating recurrent miscarriage.
Team Miracle Cyprus IVF Centre explains that chromosomal abnormalities can be associated with miscarriage and implantation failure. The Centre offers Preimplantation Genetic Testing (PGT) as part of IVF treatment.
PGT involves testing embryos before transfer for specific genetic or chromosomal abnormalities. The Centre states that PGT may be considered for patients with a history of recurrent miscarriage, although it is not required for every IVF patient.
4. PGT for Chromosomal Abnormalities
Team Miracle Cyprus IVF Centre also offers Next Generation Sequencing (NGS) for embryo screening.
The Centre states that NGS can assess all 23 pairs of chromosomes and identify abnormalities such as aneuploidy, as well as mosaicism and certain structural abnormalities.
The Centre specifically recommends NGS for patients who have experienced unexplained spontaneous miscarriages, implantation failure or are over the age of 35.
Whether this testing is appropriate for you should be determined by your fertility specialist.
5. Uterine and Endometrial Assessment
The environment in which an embryo implants can also be considered after unsuccessful IVF or repeated pregnancy loss.
Team Miracle Cyprus IVF Centre identifies uterine factors such as fibroids, polyps and a thin endometrial lining as possible factors affecting implantation.
Depending on your history, your fertility specialist may therefore recommend further investigation of the uterus before another embryo transfer.
6. Endometrial Receptivity Assessment
The timing of embryo implantation may also be investigated in selected patients.
Team Miracle Cyprus IVF Centre discusses Endometrial Receptivity Analysis (ERA) as a possible additional investigation following unsuccessful IVF treatment. The test is intended to assess the timing of the endometrial implantation window.
It should not be assumed that ERA is necessary for every patient. Your fertility specialist should determine whether this investigation is appropriate for your individual circumstances.
7. Sperm Testing
Pregnancy loss is not only related to female fertility factors. Sperm quality can also be considered when reviewing fertility history.
Team Miracle Cyprus IVF Centre discusses sperm DNA fragmentation testing as an additional investigation that may be considered following repeated unsuccessful IVF treatment.
The Centre also offers specialised sperm-selection techniques, including IMSI, for selected male fertility situations.
8. Immune-Related Assessment
Immune testing is another area sometimes discussed following repeated IVF failure or pregnancy loss.
Team Miracle Cyprus IVF Centre’s FAQ explains that immune testing remains an area where fertility specialists have limited understanding and that different laboratories may produce inconsistent results. The Centre therefore does not suggest that every patient should automatically undergo immune testing.
Patients who are concerned about possible immune factors should discuss their circumstances with their coordinator and medical team.
Does Everyone Need All These Tests?
No.
There is no single testing programme that applies to every patient who has experienced multiple miscarriages.
Your fertility specialist will consider factors such as:
- Your previous pregnancy history
- Previous IVF treatment
- Embryo development
- Previous implantation outcomes
- Your fertility test results
- Your medical history
Team Miracle Cyprus IVF Centre states that every patient requires an individual assessment before treatment begins.
Can IVF Help After Multiple Miscarriages?
IVF may be considered for patients with recurrent miscarriage, depending on their individual circumstances. Team Miracle Cyprus IVF Centre lists recurrent miscarriage among the situations in which patients may seek IVF treatment.
Where appropriate, additional embryo testing such as PGT or NGS may form part of an individualised treatment plan. However, testing does not guarantee a successful pregnancy.
The appropriate approach should be determined following a consultation with your fertility specialist.
Frequently Asked Questions
What tests are recommended after multiple miscarriages?
Depending on your circumstances, your fertility specialist may consider hormone testing, ultrasound assessment, genetic or chromosomal testing, uterine assessment, sperm testing and selected additional investigations.
Can genetic testing be used after recurrent miscarriage?
Yes. Team Miracle Cyprus IVF Centre states that PGT may be considered for patients with a history of recurrent miscarriage.
Is NGS recommended after unexplained miscarriages?
Team Miracle Cyprus IVF Centre specifically recommends NGS for patients who have previously experienced unexplained spontaneous miscarriages, implantation failure or are over the age of 35.
Should I have immune testing after multiple miscarriages?
Not necessarily. Team Miracle Cyprus IVF Centre explains that immune testing remains an area with limitations and should be discussed with the fertility team based on your individual circumstances.
What should I do before starting IVF after multiple miscarriages?
Start with an individual consultation. Your fertility specialist can review your previous pregnancies, fertility history and existing test results before recommending any additional investigations.
Discuss Your Next IVF Step With Team Miracle Cyprus IVF Centre
Multiple miscarriages can raise many questions about what to investigate before trying again. A detailed review of your fertility and pregnancy history can help your medical team determine which tests, if any, may be appropriate.
Contact Team Miracle Cyprus IVF Centre to discuss your previous pregnancy history and explore a personalised IVF treatment plan with the Team Miracle team.
